Animal clocks: when science meets nature

Animal clocks: when science meets nature.

Daily rhythms of physiology and behaviour are governed by an endogenous timekeeping mechanism (a circadian 'clock'), with the alternation of environmental light and darkness synchronizing (entraining) these rhythms to the natural day-night cycle. Our knowledge of the circadian system of animals at the molecular, cellular, tissue and organismal levels is remarkable, and we are beginning to under...

When Science Meets Religion

BEZ235: When Promising Science Meets Clinical Reality

In the July 2016 issue of The Oncologist, Carlo et al. report the results of a phase I clinical trial [1] of BEZ235 in patients with advancedrenal cell carcinoma(RCC).BEZ235 isadualpan-class PI3K and mTOR inhibitor currently undergoing phase I/II clinical trials as a single agent or in combination in solid tumors and hematologic malignancies. The authors are to be congratulated for reportingthe...

5. Essence and Natural Kinds: When Science Meets Preschooler Intuition

It is common practice in philosophy to “rely on intuitions” in the course of an argument, or sometimes simply to establish a conclusion. One question that is therefore important to settle is: what is the source of these intuitions? Correspondingly: what is their epistemological status? Philosophical discussion often proceeds as though these intuitions stem from insight into the nature of things...

Understanding complex systems: When Big Data meets network science

Better understanding and controlling complex systems has become a grand challenge not only for computer science, but also for the natural and social sciences. Many of these systems have in common that they can be studied from a network perspective. Consequently methods from network science have proven instrumental in their analysis. In this article, I introduce the macroscopic perspective that ...